YOR330C

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Systematic name YOR330C
Gene name MIP1
Aliases
Feature type ORF, Verified
Coordinates Chr XV:943385..939621
Primary SGDID S000005857


Description of YOR330C: Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit[1][2][3][4][5][6]




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References

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  1. Baruffini E, et al. (2011) Predicting the contribution of novel POLG mutations to human disease through analysis in yeast model. Mitochondrion 11(1):182-90 SGD PMID 20883824
  2. Foury F (1989) Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase. J Biol Chem 264(34):20552-60 SGD PMID 2684980
  3. Lucas P, et al. (2004) Absence of accessory subunit in the DNA polymerase gamma purified from yeast mitochondria. Mitochondrion 4(1):13-20 SGD PMID 16120369
  4. Stewart JD, et al. (2010) Polymerase gamma gene POLG determines the risk of sodium valproate-induced liver toxicity. Hepatology 52(5):1791-6 SGD PMID 21038416
  5. Stuart GR, et al. (2006) Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Hum Mol Genet 15(2):363-74 SGD PMID 16368709
  6. Young MJ, et al. (2006) The carboxyl-terminal extension on fungal mitochondrial DNA polymerases: identification of a critical region of the enzyme from Saccharomyces cerevisiae. Yeast 23(2):101-16 SGD PMID 16491467

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