YIR002C
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| Systematic name | YIR002C |
| Gene name | MPH1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:360396..357415 |
| Primary SGDID | S000001441 |
Description of YIR002C: Member of the DEAH family of 3'-5' DNA helicases; functions in an error-free DNA damage bypass pathway that involves homologous recombination, where it binds to flap DNA and stimulates the activity of Rad27p and Dna2p; mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks[1][2][3][4][5]
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References
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- ↑ Kang YH, et al. (2009) The MPH1 Gene of Saccharomyces cerevisiae Functions in Okazaki Fragment Processing. J Biol Chem 284(16):10376-86 SGD PMID 19181670
- ↑ Meetei AR, et al. (2005) A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet 37(9):958-63 SGD PMID 16116422
- ↑ Scheller J, et al. (2000) MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage. Genetics 155(3):1069-81 SGD PMID 10880470
- ↑ Schurer KA, et al. (2004) Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. Genetics 166(4):1673-86 SGD PMID 15126389
- ↑ Yan Z, et al. (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 37(6):865-78 SGD PMID 20347428
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