YNL163C
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| Systematic name | YNL163C |
| Gene name | RIA1 |
| Aliases | EFL1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:330073..326741 |
| Primary SGDID | S000005107 |
Description of YNL163C: Cytoplasmic GTPase involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes[1][2][3][4][5]
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References
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- ↑ Becam AM, et al. (2001) Ria1p (Ynl163c), a protein similar to elongation factors 2, is involved in the biogenesis of the 60S subunit of the ribosome in Saccharomyces cerevisiae. Mol Genet Genomics 266(3):454-62 SGD PMID 11713675
- ↑ Finch AJ, et al. (2011) Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev 25(9):917-29 SGD PMID 21536732
- ↑ Gartmann M, et al. (2010) Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. J Biol Chem 285(20):14848-51 SGD PMID 20356839
- ↑ Menne TF, et al. (2007) The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet 39(4):486-95 SGD PMID 17353896
- ↑ Senger B, et al. (2001) The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis. Mol Cell 8(6):1363-73 SGD PMID 11779510
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