YER068W

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Systematic name YER068W
Gene name MOT2
Aliases NOT4, SIG1
Feature type ORF, Verified
Coordinates Chr V:293050..294813
Primary SGDID S000000870


Description of YER068W: Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications[1][2][3][4][5][6]




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References

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  1. Badarinarayana V, et al. (2000) Functional interaction of CCR4-NOT proteins with TATAA-binding protein (TBP) and its associated factors in yeast. Genetics 155(3):1045-54 SGD PMID 10880468
  2. Bai Y, et al. (1999) The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5. Mol Cell Biol 19(10):6642-51 SGD PMID 10490603
  3. Denis CL, et al. (2001) Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Genetics 158(2):627-34 SGD PMID 11404327
  4. Liu HY, et al. (1998) The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J 17(4):1096-106 SGD PMID 9463387
  5. Mersman DP, et al. (2009) Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes Dev 23(8):951-62 SGD PMID 19346402
  6. Panasenko O, et al. (2006) The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex. J Biol Chem 281(42):31389-98 SGD PMID 16926149

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