YBR136W
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| Systematic name | YBR136W |
| Gene name | MEC1 |
| Aliases | ESR1, RAD31, SAD3 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:505668..512774 |
| Primary SGDID | S000000340 |
Description of YBR136W: Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres[1][2][3][4][5][6][7]
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References
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- ↑ Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 SGD PMID 8939848
- ↑ Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 SGD PMID 10511543
- ↑ Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () SGD PMID 22289863
- ↑ Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 SGD PMID 8065923
- ↑ Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 SGD PMID 8744945
- ↑ Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 SGD PMID 9610409
- ↑ Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65 SGD PMID 7926756
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