YPR181C
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| Systematic name | YPR181C |
| Gene name | SEC23 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:899667..897361 |
| Primary SGDID | S000006385 |
Description of YPR181C: GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p[1][2][3][4]
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References
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- ↑ Barlowe C, et al. (1994) COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell 77(6):895-907 SGD PMID 8004676
- ↑ Duden R (2003) ER-to-Golgi transport: COP I and COP II function (Review). Mol Membr Biol 20(3):197-207 SGD PMID 12893528
- ↑ Ossareh-Nazari B, et al. (2010) The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23. Exp Cell Res 316(20):3351-7 SGD PMID 20846524
- ↑ Yoshihisa T, et al. (1993) Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum. Science 259(5100):1466-8 SGD PMID 8451644
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