YPR018W
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| Systematic name | YPR018W |
| Gene name | RLF2 |
| Aliases | CAC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:594476..596296 |
| Primary SGDID | S000006222 |
Description of YPR018W: Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription[1][2][3][4][5][6][7][8][9][10]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [11] [12]
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References
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- ↑ Enomoto S and Berman J (1998) Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci. Genes Dev 12(2):219-32 SGD PMID 9436982
- ↑ Game JC and Kaufman PD (1999) Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo. Genetics 151(2):485-97 SGD PMID 9927445
- ↑ Glowczewski L, et al. (2004) Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus. Mol Cell Biol 24(23):10180-92 SGD PMID 15542829
- ↑ Kaufman PD, et al. (1997) Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Genes Dev 11(3):345-57 SGD PMID 9030687
- ↑ Kim HJ, et al. (2009) Potential role of the histone chaperone, CAF-1, in transcription. BMB Rep 42(4):227-31 SGD PMID 19403047
- ↑ Kim JA and Haber JE (2009) Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete. Proc Natl Acad Sci U S A 106(4):1151-6 SGD PMID 19164567
- ↑ Sharp JA, et al. (2002) Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae. Genes Dev 16(1):85-100 SGD PMID 11782447
- ↑ Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97 SGD PMID 10082585
- ↑ Zabaronick SR and Tyler JK (2005) The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase. Mol Cell Biol 25(2):652-60 SGD PMID 15632066
- ↑ Zhou H, et al. (2006) Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair. Biochemistry 45(9):2852-61 SGD PMID 16503640
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-29
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