YPL157W

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Systematic name YPL157W
Gene name TGS1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:254814..255761
Primary SGDID S000006078


Description of YPL157W: Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs[1][2][3][4]




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References

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  1. Colau G, et al. (2004) The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology. Mol Cell Biol 24(18):7976-86 SGD PMID 15340060
  2. Franke J, et al. (2008) Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1. J Cell Sci 121(Pt 21):3553-60 SGD PMID 18840651
  3. Mouaikel J, et al. (2002) Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. Mol Cell 9(4):891-901 SGD PMID 11983179
  4. Qiu ZR, et al. (2011) An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs. Nucleic Acids Res () SGD PMID 21398639

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