YPL008W
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| Systematic name | YPL008W |
| Gene name | CHL1 |
| Aliases | CTF1, LPA9, MCM12 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:539385..541970 |
| Primary SGDID | S000005929 |
Description of YPL008W: Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome[1][2][3][4]
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References
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- Jump up ↑ Das SP and Sinha P (2005) The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging. Biochem Biophys Res Commun 337(1):167-72 SGD PMID 16182251
- Jump up ↑ Skibbens RV (2004) Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics 166(1):33-42 SGD PMID 15020404
- Jump up ↑ Wu Y, et al. (2009) Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci 66(7):1209-22 SGD PMID 19099189
- Jump up ↑ Wu Y, et al. (2011) Biochemical characterization of Warsaw Breakage Syndrome helicase. J Biol Chem () SGD PMID 22102414
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