YNR011C

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Systematic name YNR011C
Gene name PRP2
Aliases RNA2
Feature type ORF, Verified
Coordinates Chr XIV:646950..644320
Primary SGDID S000005294


Description of YNR011C: RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16[1][2]




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References

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  1. Gencheva M, et al. (2010) Nuclear Retention of Unspliced Pre-mRNAs by Mutant DHX16/hPRP2, a Spliceosomal DEAH-box Protein. J Biol Chem 285(46):35624-32 SGD PMID 20841358
  2. Kim SH and Lin RJ (1996) Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing. Mol Cell Biol 16(12):6810-9 SGD PMID 8943336

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