YNL305C
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| Systematic name | YNL305C |
| Gene name | BXI1 |
| Aliases | YBH3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:59791..58898 |
| Primary SGDID | S000005249 |
Description of YNL305C: Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p[1][2][3][4][5]
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References
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- Jump up ↑ Buttner S, et al. (2011) A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis.LID - 10.1038/emboj.2011.197 [doi] EMBO J () SGD PMID 21673659
- Jump up ↑ Cebulski J, et al. (2011) Yeast Bax Inhibitor, Bxi1p, Is an ER-Localized Protein That Links the Unfolded Protein Response and Programmed Cell Death in Saccharomyces cerevisiae. PLoS One 6(6):e20882 SGD PMID 21673967
- Jump up ↑ Chae HJ, et al. (2003) Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast. Gene 323():101-13 SGD PMID 14659883
- Jump up ↑ Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 SGD PMID 12140549
- Jump up ↑ Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
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