YNL167C

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Systematic name YNL167C
Gene name SKO1
Aliases ACR1
Feature type ORF, Verified
Coordinates Chr XIV:321359..319416
Primary SGDID S000005111


Description of YNL167C: Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses[1][2][3][4][5][6]




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References

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  1. Nehlin JO, et al. (1992) Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription. Nucleic Acids Res 20(20):5271-8 SGD PMID 1437546
  2. Pascual-Ahuir A, et al. (2001) Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress. J Biol Chem 276(40):37373-8 SGD PMID 11500510
  3. Proft M and Struhl K (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17 SGD PMID 12086627
  4. Rep M, et al. (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40(5):1067-83 SGD PMID 11401713
  5. Serrano R and Rodriguez-Navarro A (2001) Ion homeostasis during salt stress in plants. Curr Opin Cell Biol 13(4):399-404 SGD PMID 11454443
  6. Tomas-Cobos L, et al. (2004) Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways. J Biol Chem 279(21):22010-9 SGD PMID 15014083

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