YMR296C
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| Systematic name | YMR296C |
| Gene name | LCB1 |
| Aliases | END8, TSC2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:860891..859215 |
| Primary SGDID | S000004911 |
Description of YMR296C: Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine[1][2]
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References
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- ↑ Buede R, et al. (1991) Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids. J Bacteriol 173(14):4325-32 SGD PMID 2066332
- ↑ Nagiec MM, et al. (1994) The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci U S A 91(17):7899-902 SGD PMID 8058731
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