YLR423C
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| Systematic name | YLR423C |
| Gene name | ATG17 |
| Aliases | APG17 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:973170..971917 |
| Primary SGDID | S000004415 |
Description of YLR423C: Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells[1][2][3][4][5]
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References
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- ↑ Cheong H, et al. (2005) Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell 16(7):3438-53 SGD PMID 15901835
- ↑ Kabeya Y, et al. (2005) Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 16(5):2544-53 SGD PMID 15743910
- ↑ Morselli E, et al. (2011) p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200. Cell Cycle 10(16) SGD PMID 21775823
- ↑ Suzuki K, et al. (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12(2):209-18 SGD PMID 17295840
- ↑ Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160
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