YDR519W

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Systematic name YDR519W
Gene name FPR2
Aliases FKB2
Feature type ORF, Verified
Coordinates Chr IV:1480425..1480832
Primary SGDID S000002927


Description of YDR519W: Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking[1][2][3]




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References

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  1. Nielsen JB, et al. (1992) Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2. Proc Natl Acad Sci U S A 89(16):7471-5 SGD PMID 1380159
  2. Partaledis JA and Berlin V (1993) The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Proc Natl Acad Sci U S A 90(12):5450-4 SGD PMID 7685904
  3. Partaledis JA, et al. (1992) Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein. Yeast 8(8):673-80 SGD PMID 1279908

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