YDR419W
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| Systematic name | YDR419W |
| Gene name | RAD30 |
| Aliases | DBH1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1303174..1305072 |
| Primary SGDID | S000002827 |
Description of YDR419W: DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV[1][2][3][4]
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References
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- ↑ Johnson RE, et al. (1999) Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science 283(5404):1001-4 SGD PMID 9974380
- ↑ Masutani C, et al. (1999) The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature 399(6737):700-4 SGD PMID 10385124
- ↑ Prakash S, et al. (2005) Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem 74:317-53 SGD PMID 15952890
- ↑ Yuan F, et al. (2000) Specificity of DNA lesion bypass by the yeast DNA polymerase eta. J Biol Chem 275(11):8233-9 SGD PMID 10713149
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