YDR400W

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Systematic name YDR400W
Gene name URH1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1271063..1272085
Primary SGDID S000002808


Description of YDR400W: Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways[1][2][3][4]




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References

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  1. Belenky P, et al. (2007) Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 129(3):473-84 SGD PMID 17482543
  2. Kurtz JE, et al. (1999) New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Curr Genet 36(3):130-6 SGD PMID 10501935
  3. Kurtz JE, et al. (2002) The URH1 uridine ribohydrolase of Saccharomyces cerevisiae. Curr Genet 41(3):132-41 SGD PMID 12111094
  4. Mitterbauer R, et al. (2002) Saccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase. Appl Environ Microbiol 68(3):1336-43 SGD PMID 11872485

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