YDR180W
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| Systematic name | YDR180W |
| Gene name | SCC2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:821295..825776 |
| Primary SGDID | S000002588 |
Description of YDR180W: Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin[1][2][3][4][5]
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Community Commentary
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References
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- ↑ Ciosk R, et al. (2000) Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell 5(2):243-54 SGD PMID 10882066
- ↑ Furuya K, et al. (1998) Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev 12(21):3408-18 SGD PMID 9808627
- ↑ Michaelis C, et al. (1997) Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91(1):35-45 SGD PMID 9335333
- ↑ Strom L, et al. (2004) Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. Mol Cell 16(6):1003-15 SGD PMID 15610742
- ↑ Unal E, et al. (2004) DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 16(6):991-1002 SGD PMID 15610741
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