YDL164C

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Systematic name YDL164C
Gene name CDC9
Aliases MMS8
Feature type ORF, Verified
Coordinates Chr IV:167254..164987
Primary SGDID S000002323


Description of YDL164C: DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination[1][2][3][4][5][6]




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References

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  1. Johnston LH and Nasmyth KA (1978) Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase. Nature 274(5674):891-3 SGD PMID 355897
  2. Lindahl T and Barnes DE (1992) Mammalian DNA ligases. Annu Rev Biochem 61:251-81 SGD PMID 1497311
  3. Waga S and Stillman B (1998) The DNA replication fork in eukaryotic cells. Annu Rev Biochem 67:721-51 SGD PMID 9759502
  4. Willer M, et al. (1999) The yeast CDC9 gene encodes both a nuclear and a mitochondrial form of DNA ligase I. Curr Biol 9(19):1085-94 SGD PMID 10531002
  5. Wu X, et al. (1999) DNA ligation during excision repair in yeast cell-free extracts is specifically catalyzed by the CDC9 gene product. Biochemistry 38(9):2628-35 SGD PMID 10052932
  6. Zou H and Rothstein R (1997) Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell 90(1):87-96 SGD PMID 9230305

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