YKR089C
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| Systematic name | YKR089C |
| Gene name | TGL4 |
| Aliases | STC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:608365..605633 |
| Primary SGDID | S000001797 |
Description of YKR089C: Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p[1][2][3][4]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Together with: TGL3
Phenotype(s): Loss of function (Null), Recessive, Viable
tgl3 tgl4 double mutants are unable to degrade triglycerides in lag and early log-phases of growth [1] [5]
Protein Details
Protein Function/Process
Together with: TGL3
Triglyceride lipase activity; Functional complementation of tgl4 mutants by murine ATGL, Adipose Triglyceride Lipase [1] [5]
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [6]
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References
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- ↑ 1.0 1.1 1.2 Kurat CF, et al. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem 281(1):491-500 SGD PMID 16267052
- ↑ Kurat CF, et al. (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell 33(1):53-63 SGD PMID 19150427
- ↑ Rajakumari S and Daum G (2010) Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae. J Biol Chem 285(21):15769-76 SGD PMID 20332534
- ↑ 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ 5.0 5.1 submitted by Sepp D. Kohlwein on 2006-05-22
- ↑ submitted by Jeff Ubersax on 2004-01-29
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
- Pages with reference errors
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains
- Phenotype:Loss of function (Null)
- Phenotype:Recessive
- Phenotype:Viable
- Topic:Protein Details
- Topic:Protein Details:Protein Function/Process
- Topic:Protein Details:Protein Modification
- Modification:Phosphorylation
