YIL046W

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Systematic name YIL046W
Gene name MET30
Aliases ZRG11
Feature type ORF, Verified
Coordinates Chr IX:268651..270573
Primary SGDID S000001308


Description of YIL046W: F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus[1][2]




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Interactions

Other Interactions

Other Topic: NOT Regulatory Other Interactions interaction with SWE1
Despite previous reports to the contrary, Met30p is not required for Swe1p degradation [3] [4]





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References

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  1. Rouillon A, et al. (2000) Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex. EMBO J 19(2):282-94 SGD PMID 10637232
  2. Smothers DB, et al. (2000) The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability. Mol Cell Biol 20(21):7845-52 SGD PMID 11027256
  3. McMillan JN, et al. (2002) Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3560-75 SGD PMID 12388757
  4. submitted by Daniel Lew on 2003-03-03

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