YHR119W
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| Systematic name | YHR119W |
| Gene name | SET1 |
| Aliases | YTX1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:346043..349285 |
| Primary SGDID | S000001161 |
Description of YHR119W: Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain[1][2][3][4][5][6]
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References
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- ↑ Boa S, et al. (2003) Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression. Yeast 20(9):827-35 SGD PMID 12845608
- ↑ Cheng H, et al. (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43 SGD PMID 15024081
- ↑ Dover J, et al. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71 SGD PMID 12070136
- ↑ Krogan NJ, et al. (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5 SGD PMID 11805083
- ↑ Miller T, et al. (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7 SGD PMID 11687631
- ↑ Terzi N, et al. (2011) H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol () SGD PMID 21709022
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