YDR096W
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| Systematic name | YDR096W |
| Gene name | GIS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:637139..639823 |
| Primary SGDID | S000002503 |
Description of YDR096W: JmjC domain-containing histone demethylase and transcription factor; involved in expression of genes during nutrient limitation; negatively regulates DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis; has a JmjC and a JmjN domain in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity; contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain[1][2][3][4][5][6][7]
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References
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- ↑ Balciunas D and Ronne H (1999) Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Mol Gen Genet 262(4-5):589-99 SGD PMID 10628841
- ↑ Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 SGD PMID 10523651
- ↑ Oshiro J, et al. (2003) Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p. J Biol Chem 278(34):31495-503 SGD PMID 12799368
- ↑ Pedruzzi I, et al. (2000) Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J 19(11):2569-79 SGD PMID 10835355
- ↑ Quan Z, et al. (2011) JmjN interacts with JmjC to ensure selective degradation of Gis1 by the proteasome. Microbiology () SGD PMID 21680636
- ↑ Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 SGD PMID 17369256
- ↑ Zhang N and Oliver SG (2010) The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis. J Biol Chem 285(9):6465-76 SGD PMID 20022953
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