YCL051W

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Systematic name YCL051W
Gene name LRE1
Aliases
Feature type ORF, Verified
Coordinates Chr III:35865..37616
Primary SGDID S000000556


Description of YCL051W: Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway[1][2][3]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]





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References

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  1. Alonso-Monge R, et al. (2001) Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects. Mol Microbiol 41(3):717-30 SGD PMID 11532139
  2. Lai MH, et al. (1997) Multiple copies of PBS2, MHP1 or LRE1 produce glucanase resistance and other cell wall effects in Saccharomyces cerevisiae. Yeast 13(3):199-213 SGD PMID 9090049
  3. Versele M and Thevelein JM (2001) Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae. Mol Microbiol 41(6):1311-26 SGD PMID 11580836
  4. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  5. submitted by Jeff Ubersax on 2004-01-21

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