YPR033C
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| Systematic name | YPR033C |
| Gene name | HTS1 |
| Aliases | TSM4572 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:639019..637379 |
| Primary SGDID | S000006237 |
Description of YPR033C: Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome[1][2][3]
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References
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- ↑ Chiu MI, et al. (1992) HTS1 encodes both the cytoplasmic and mitochondrial histidyl-tRNA synthetase of Saccharomyces cerevisiae: mutations alter the specificity of compartmentation. Genetics 132(4):987-1001 SGD PMID 1459448
- ↑ Natsoulis G, et al. (1986) The HTS1 gene encodes both the cytoplasmic and mitochondrial histidine tRNA synthetases of S. cerevisiae. Cell 46(2):235-43 SGD PMID 3521891
- ↑ Pierce SB, et al. (2011) Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proc Natl Acad Sci U S A 108(16):6543-8 SGD PMID 21464306
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