YJL090C

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Systematic name YJL090C
Gene name DPB11
Aliases
Feature type ORF, Verified
Coordinates Chr X:265046..262752


Description of YJL090C: Essential BRCT repeat protein, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control[1][2][3][4][5][6]




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References

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  1. Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 SGD PMID 12865298
  2. Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 SGD PMID 11973288
  3. Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 SGD PMID 9742127
  4. Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 SGD PMID 10545450
  5. Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 SGD PMID 10097122
  6. Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 SGD PMID 10733584

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