YLR359W

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Systematic name YLR359W
Gene name ADE13
Aliases BRA1, BRA8
Feature type ORF, Verified
Coordinates Chr XII:844282..845730
Primary SGDID S000004351


Description of YLR359W: Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency[1][2][3]




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References

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  1. Denis V, et al. (1998) Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis. Mol Microbiol 30(3):557-66 SGD PMID 9822821
  2. Jones EW and Fink GR (1982) Regulation of amino acid and nucleotide biosynthesis in yeast. Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press SGD PMID
  3. Van den Berghe G, et al. (1997) Inborn errors of the purine nucleotide cycle: adenylosuccinase deficiency. J Inherit Metab Dis 20(2):193-202 SGD PMID 9211192

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