YGR232W
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| Systematic name | YGR232W |
| Gene name | NAS6 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:953960..954646 |
| Primary SGDID | S000003464 |
Description of YGR232W: Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6[1][2][3][4][5]
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References
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- ↑ Funakoshi M, et al. (2009) Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell 137(5):887-99 SGD PMID 19446322
- ↑ Hori T, et al. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216(1):113-22 SGD PMID 9714768
- ↑ Padmanabhan B, et al. (2004) Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J Biol Chem 279(2):1546-52 SGD PMID 14583612
- ↑ Roelofs J, et al. (2009) Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature 459(7248):861-5 SGD PMID 19412159
- ↑ Saeki Y, et al. (2009) Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell 137(5):900-13 SGD PMID 19446323
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