YGL207W

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Systematic name YGL207W
Gene name SPT16
Aliases CDC68, SSF1
Feature type ORF, Verified
Coordinates Chr VII:98969..102076
Primary SGDID S000003175


Description of YGL207W: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases[1][2][3][4]




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References

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  1. Belotserkovskaya R, et al. (2003) FACT facilitates transcription-dependent nucleosome alteration. Science 301(5636):1090-3 SGD PMID 12934006
  2. Formosa T, et al. (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71 SGD PMID 12524332
  3. Ransom M, et al. (2009) FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation. J Biol Chem 284(35):23461-71 SGD PMID 19574230
  4. Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 SGD PMID 19683499

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