YDR399W
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| Systematic name | YDR399W |
| Gene name | HPT1 |
| Aliases | BRA6, HPRT |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1270068..1270733 |
| Primary SGDID | S000002807 |
Description of YDR399W: Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome[1][2][3]
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References
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- ↑ Ali LZ and Sloan DL (1982) Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast. J Biol Chem 257(3):1149-55 SGD PMID 7035445
- ↑ Ali LZ and Sloan DL (1986) Activation of hypoxanthine/guanine phosphoribosyltransferase from yeast by divalent zinc and nickel ions. J Inorg Biochem 28(4):407-15 SGD PMID 3546595
- ↑ Nussbaum RL and Caskey CT (1981) Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 20(16):4584-90 SGD PMID 6170313
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