YAL026C
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| Systematic name | YAL026C |
| Gene name | DRS2 |
| Aliases | FUN38, SWA3 |
| Feature type | ORF, Verified |
| Coordinates | Chr I:99697..95630 |
| Primary SGDID | S000000024 |
Description of YAL026C: Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease[1][2][3][4][5][6]
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References
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- ↑ Alder-Baerens N, et al. (2006) Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Mol Biol Cell 17(4):1632-42 SGD PMID 16452632
- ↑ Bull LN, et al. (1998) A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 18(3):219-24 SGD PMID 9500542
- ↑ Chen CY, et al. (1999) Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function. J Cell Biol 147(6):1223-36 SGD PMID 10601336
- ↑ Gall WE, et al. (2002) Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo. Curr Biol 12(18):1623-7 SGD PMID 12372257
- ↑ Natarajan P, et al. (2004) Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Proc Natl Acad Sci U S A 101(29):10614-9 SGD PMID 15249668
- ↑ Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 SGD PMID 12631737
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