YLR205C

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Systematic name YLR205C
Gene name HMX1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:553679..552726
Primary SGDID S000004195


Description of YLR205C: ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants[1][2][3][4][5]




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References

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  1. Auclair K, et al. (2003) Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif 28(2):340-9 SGD PMID 12699699
  2. Collinson EJ, et al. (2010) The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes. J Biol Chem () SGD PMID 21081499
  3. Foury F and Talibi D (2001) Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. J Biol Chem 276(11):7762-8 SGD PMID 11112771
  4. Kim D, et al. (2006) Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans. Biochemistry 45(49):14772-80 SGD PMID 17144670
  5. Protchenko O and Philpott CC (2003) Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J Biol Chem 278(38):36582-7 SGD PMID 12840010

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