YNL239W
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Systematic name | YNL239W |
Gene name | LAP3 |
Aliases | BLH1, GAL6, YCP1 |
Feature type | ORF, Verified |
Coordinates | Chr XIV:200570..201934 |
Primary SGDID | S000005183 |
Description of YNL239W: Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH[1][2][3][4][5]
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References
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- ↑ Ferrando AA, et al. (1996) Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. Cancer Res 56(8):1746-50 SGD PMID 8620487
- ↑ Kambouris NG, et al. (1992) Cloning and characterization of a cysteine proteinase from Saccharomyces cerevisiae. J Biol Chem 267(30):21570-6 SGD PMID 1400467
- ↑ Xu HE and Johnston SA (1994) Yeast bleomycin hydrolase is a DNA-binding cysteine protease. Identification, purification, biochemical characterization. J Biol Chem 269(33):21177-83 SGD PMID 8063738
- ↑ Zheng W, et al. (1997) The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast. J Biol Chem 272(48):30350-5 SGD PMID 9374524
- ↑ Zimny J, et al. (2006) Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. J Biol Chem 281(32):22485-92 SGD PMID 16769724
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