YNL072W
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| Systematic name | YNL072W |
| Gene name | RNH201 |
| Aliases | RNH35 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:490319..491242 |
| Primary SGDID | S000005016 |
Description of YNL072W: Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of RNAse HI (the S. cerevisiae homolog of mammalian RNAse HII is RNH1); related to human AGS4 that causes Aicardi-Goutieres syndrome[1][2][3]
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References
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- ↑ Crow YJ, et al. (2006) Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet 38(8):910-6 SGD PMID 16845400
- ↑ Frank P, et al. (1998) Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII. FEBS Lett 421(1):23-6 SGD PMID 9462832
- ↑ Qiu J, et al. (1999) Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol 19(12):8361-71 SGD PMID 10567561
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