YOL025W

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Systematic name YOL025W
Gene name LAG2
Aliases ECM36
Feature type ORF, Verified
Coordinates Chr XV:274958..276940
Primary SGDID S000005385


Description of YOL025W: Protein involved in the determination of longevity and also in the negative regulation of SCF E3-ubiquitin ligase function; LAG2 is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells[1][2]




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References

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  1. ↑ Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 SGD PMID 8760941
  2. ↑ Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J SGD PMID 19763088

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