YOR377W

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Systematic name YOR377W
Gene name ATF1
Aliases
Feature type ORF, Verified
Coordinates Chr XV:1046224..1047801
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Description of YOR377W: Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation[1][2][3]



Interactions

Genetic

Strain Background: S288C, W303, industrial
Genetic interaction with TPK2, TPK3
Mutation type(s): deletion/partial inactivating

ATF1 is transcriptionally induced by glucose and sucrose. This regulation depends on Ras/cAMP/PKA signaling. Long-term expression of ATF1 requires both a fermentable carbon source and a nitrogen source. This regulation depends on FGM signaling. [4] [5]


Strain Background: S288C, W303, industrial
Genetic interaction with TPK1
Mutation type(s): deletion/partial inactivating

ATF1 is transcriptionally induced by glucose and sucrose. This regulation depends on Ras/cAMP/PKA signaling. Long-term expression of ATF1 requires both a fermentable carbon source and a nitrogen source. This regulation depends on FGM signaling. [4] [6]


Community Commentary

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Interactions

Genetic

Strain Background: S288C, W303, industrial
Genetic interaction with TPK2, TPK3
Mutation type(s): deletion/partial inactivating

ATF1 is transcriptionally induced by glucose and sucrose. This regulation depends on Ras/cAMP/PKA signaling. Long-term expression of ATF1 requires both a fermentable carbon source and a nitrogen source. This regulation depends on FGM signaling. [4] [5]


Strain Background: S288C, W303, industrial
Genetic interaction with TPK1
Mutation type(s): deletion/partial inactivating

ATF1 is transcriptionally induced by glucose and sucrose. This regulation depends on Ras/cAMP/PKA signaling. Long-term expression of ATF1 requires both a fermentable carbon source and a nitrogen source. This regulation depends on FGM signaling. [4] [6]


References

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  1. Verstrepen KJ, et al. (2003) Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters. Appl Environ Microbiol 69(9):5228-37 SGD PMID 12957907
  2. Mason AB and Dufour JP (2000) Alcohol acetyltransferases and the significance of ester synthesis in yeast. Yeast 16(14):1287-98 SGD PMID 11015726
  3. Fujii T, et al. (1994) Molecular cloning, sequence analysis, and expression of the yeast alcohol acetyltransferase gene. Appl Environ Microbiol 60(8):2786-92 SGD PMID 8085822
  4. 4.0 4.1 4.2 4.3 Verstrepen KJ, et al. (2003) The Saccharomyces cerevisiae alcohol acetyl transferase gene ATF1 is a target of the cAMP/PKA and FGM nutrient-signalling pathways. FEMS Yeast Res 4(3):285-96 SGD PMID 14654433
  5. 5.0 5.1 submitted by Kevin J Verstrepen on 2004-03-11
  6. 6.0 6.1 submitted by Kevin J Verstrepen on 2004-03-04

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