YBR112C
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Systematic name | YBR112C | |
Gene name | CYC8 | |
Aliases | CRT8, SSN6 | |
Feature type | ORF, Verified | |
Coordinates | Chr II:465764..462864 | |
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Description of YBR112C: General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters[1][2]
Interactions
Other Interactions
Other Topic: functional dependence
Other Interactions interaction with Nrg1
Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Cyc8/Ssn6. [3] [4]
Physical
Physical interaction with Nrg1
Nrg1 interacts with Ssn6/Cyc8 in the two-hybrid system, and in GST pull-down experiments. [3] [4]
Contents
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Interactions
Other Interactions
Other Topic: functional dependence
Other Interactions interaction with Nrg1
Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Cyc8/Ssn6. [3] [4]
Physical
Physical interaction with Nrg1
Nrg1 interacts with Ssn6/Cyc8 in the two-hybrid system, and in GST pull-down experiments. [3] [4]
References
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- ↑ Proft M and Struhl K (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17 SGD PMID 12086627
- ↑ Smith RL and Johnson AD (2000) Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotes. Trends Biochem Sci 25(7):325-30 SGD PMID 10871883
- ↑ 3.0 3.1 3.2 3.3 Park SH, et al. (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50 SGD PMID 10022891
- ↑ 4.0 4.1 4.2 4.3 submitted by Valmik K. Vyas on 2003-02-12
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