YGR232W

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Systematic name YGR232W
Gene name NAS6
Aliases
Feature type ORF, Verified
Coordinates Chr VII:953963..954649
Primary SGDID S000003464


Description of YGR232W: Protein involved in the assembly of the proteasome regulatory particle (RP); homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6[1][2][3]




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References

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  1. Hori T, et al. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216(1):113-22 SGD PMID 9714768
  2. Padmanabhan B, et al. (2004) Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J Biol Chem 279(2):1546-52 SGD PMID 14583612
  3. Roelofs J, et al. (2009) Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature SGD PMID 19412159

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