YGL040C
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| Systematic name | YGL040C |
| Gene name | HEM2 |
| Aliases | OLE4, SLU1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:420561..419533 |
| Primary SGDID | S000003008 |
Description of YGL040C: Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus[1][2][3][4]
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References
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- ↑ Myers AM, et al. (1987) Characterization of the yeast HEM2 gene and transcriptional regulation of COX5 and COR1 by heme. J Biol Chem 262(35):16822-9 SGD PMID 2445751
- ↑ Gollub EG, et al. (1977) Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene. J Biol Chem 252(9):2846-54 SGD PMID 323256
- ↑ Borralho LM, et al. (1990) Purification of delta-aminolevulinate dehydratase from genetically engineered yeast. Yeast 6(4):319-30 SGD PMID 2204246
- ↑ Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
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