YPL154C
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| Systematic name | YPL154C |
| Gene name | PEP4 |
| Aliases | PHO9, PRA1, yscA |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:260930..259713 |
| Primary SGDID | S000006075 |
Description of YPL154C: Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates[1][2][3][4][5][6][7]
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References
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- ↑ Rupp S and Wolf DH (1995) Biogenesis of the yeast vacuole (lysosome). The use of active-site mutants of proteinase yscA to determine the necessity of the enzyme for vacuolar proteinase maturation and proteinase yscB stability. Eur J Biochem 231(1):115-25 SGD PMID 7628461
- ↑ van den Hazel HB, et al. (1993) The propeptide is required for in vivo formation of stable active yeast proteinase A and can function even when not covalently linked to the mature region. J Biol Chem 268(24):18002-7 SGD PMID 8349680
- ↑ van den Hazel HB, et al. (1992) Autoactivation of proteinase A initiates activation of yeast vacuolar zymogens. Eur J Biochem 207(1):277-83 SGD PMID 1628653
- ↑ Wolff AM, et al. (1996) Vacuolar and extracellular maturation of Saccharomyces cerevisiae proteinase A. Yeast 12(9):823-32 SGD PMID 8840499
- ↑ Ammerer G, et al. (1986) PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors. Mol Cell Biol 6(7):2490-9 SGD PMID 3023936
- ↑ Woolford CA, et al. (1986) The PEP4 gene encodes an aspartyl protease implicated in the posttranslational regulation of Saccharomyces cerevisiae vacuolar hydrolases. Mol Cell Biol 6(7):2500-10 SGD PMID 3537721
- ↑ Marques M, et al. (2006) The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae. Microbiology 152(Pt 12):3595-605 SGD PMID 17159212
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