YOR057W
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| Systematic name | YOR057W |
| Gene name | SGT1 |
| Aliases | YOR29-08 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:432188..433375 |
| Primary SGDID | S000005583 |
Description of YOR057W: Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes[1][2][3]
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References
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- ↑ Kitagawa K, et al. (1999) SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell 4(1):21-33 SGD PMID 10445024
- ↑ Dubacq C, et al. (2002) Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Eukaryot Cell 1(4):568-82 SGD PMID 12456005
- ↑ Catlett MG and Kaplan KB (2006) Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p. J Biol Chem 281(44):33739-48 SGD PMID 16945921
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