YLR424W

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Systematic name YLR424W
Gene name SPP382
Aliases CCF8, NTR1
Feature type ORF, Verified
Coordinates Chr XII:973392..975518
Primary SGDID S000004416


Description of YLR424W: Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation[1][2][3]




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References

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  1. Tsai RT, et al. (2005) Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2. Genes Dev 19(24):2991-3003 SGD PMID 16357217
  2. Wang Q, et al. (2003) The Clf1p splicing factor promotes spliceosome assembly through N-terminal tetratricopeptide repeat contacts. J Biol Chem 278(10):7875-83 SGD PMID 12509417
  3. Pandit S, et al. (2006) Inhibition of a spliceosome turnover pathway suppresses splicing defects. Proc Natl Acad Sci U S A 103(37):13700-5 SGD PMID 16945917

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