YLR421C
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| Systematic name | YLR421C |
| Gene name | RPN13 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:965557..965087 |
| Primary SGDID | S000004413 |
Description of YLR421C: Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability[1][2][3]
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References
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- ↑ Verma R, et al. (2000) Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol Biol Cell 11(10):3425-39 SGD PMID 11029046
- ↑ Seong KM, et al. (2007) Rpn13p and Rpn14p are involved in the recognition of ubiquitinated Gcn4p by the 26S proteasome. FEBS Lett 581(13):2567-73 SGD PMID 17499717
- ↑ Husnjak K, et al. (2008) Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453(7194):481-488 SGD PMID 18497817
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