YLR220W
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| Systematic name | YLR220W |
| Gene name | CCC1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:576827..577795 |
| Primary SGDID | S000004210 |
Description of YLR220W: Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation[1][2][3]
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References
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- ↑ Chen OS and Kaplan J (2000) CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation. J Biol Chem 275(11):7626-32 SGD PMID 10713071
- ↑ Lapinskas PJ, et al. (1996) The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions. Mol Microbiol 21(3):519-28 SGD PMID 8866476
- ↑ Li L, et al. (2001) CCC1 is a transporter that mediates vacuolar iron storage in yeast. J Biol Chem 276(31):29515-9 SGD PMID 11390404
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