YJR078W
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| Systematic name | YJR078W |
| Gene name | BNA2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:578852..580213 |
| Primary SGDID | S000003839 |
Description of YJR078W: Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expresssion is upregulated upon telomere uncapping; regulated by Hst1p and Aft2p[1][2][3][4][5]
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Community Commentary
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References
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- ↑ Greenall A, et al. (2008) A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection. Genome Biol 9(10):R146 SGD PMID 18828915
- ↑ Yuasa HJ, et al. (2007) Evolution of vertebrate indoleamine 2,3-dioxygenases. J Mol Evol 65(6):705-14 SGD PMID 18026683
- ↑ Bedalov A, et al. (2003) NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol 23(19):7044-54 SGD PMID 12972620
- ↑ Rutherford JC, et al. (2003) Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem 278(30):27636-43 SGD PMID 12756250
- ↑ Panozzo C, et al. (2002) Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett 517(1-3):97-102 SGD PMID 12062417
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