YHR205W

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Systematic name YHR205W
Gene name SCH9
Aliases KOM1
Feature type ORF, Verified
Coordinates Chr VIII:509363..511837
Primary SGDID S000001248


Description of YHR205W: Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB[1][2][3][4][5][6]




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References

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  1. Pascual-Ahuir A and Proft M (2007) The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes. EMBO J 26(13):3098-108 SGD PMID 17568771
  2. Prusty R and Keil RL (2004) SCH9, a putative protein kinase from Saccharomyces cerevisiae, affects HOT1-stimulated recombination. Mol Genet Genomics 272(3):264-74 SGD PMID 15349770
  3. Fabrizio P, et al. (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292(5515):288-90 SGD PMID 11292860
  4. Morano KA and Thiele DJ (1999) The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J 18(21):5953-62 SGD PMID 10545107
  5. di Blasi F, et al. (1993) The SCH9 protein kinase mRNA contains a long 5' leader with a small open reading frame. Yeast 9(1):21-32 SGD PMID 8442384
  6. Crauwels M, et al. (1997) The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology 143 ( Pt 8):2627-37 SGD PMID 9274016

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