YER089C
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| Systematic name | YER089C |
| Gene name | PTC2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:337336..335942 |
| Primary SGDID | S000000891 |
Description of YER089C: Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation[1][2][3][4][5][6][7]
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Contents
Community Commentary
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References
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- ↑ Leroy C, et al. (2003) PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell 11(3):827-35 SGD PMID 12667463
- ↑ Young C, et al. (2002) Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation. Eukaryot Cell 1(6):1032-40 SGD PMID 12477803
- ↑ Warmka J, et al. (2001) Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Mol Cell Biol 21(1):51-60 SGD PMID 11113180
- ↑ Welihinda AA, et al. (1998) Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol Cell Biol 18(4):1967-77 SGD PMID 9528768
- ↑ Marsolier MC, et al. (2000) Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae. Genetics 154(4):1523-32 SGD PMID 10747050
- ↑ Maeda T, et al. (1993) Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae. Mol Cell Biol 13(9):5408-17 SGD PMID 8395005
- ↑ Cheng A, et al. (1999) Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev 13(22):2946-57 SGD PMID 10580002
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