YER063W

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Systematic name YER063W
Gene name THO1
Aliases
Feature type ORF, Verified
Coordinates Chr V:281708..282364
Primary SGDID S000000865


Description of YER063W: Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation[1][2]




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References

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  1. Piruat JI and Aguilera A (1998) A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. EMBO J 17(16):4859-72 SGD PMID 9707445
  2. Jimeno S, et al. (2006) Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants. Mol Cell Biol 26(12):4387-98 SGD PMID 16738307

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