YBR217W
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| Systematic name | YBR217W |
| Gene name | ATG12 |
| Aliases | APG12 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:657827..658387 |
| Primary SGDID | S000000421 |
Description of YBR217W: Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation[1][2][3][4][5][6]
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References
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- ↑ Hanada T, et al. (2007) The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy. J Biol Chem 282(52):37298-302 SGD PMID 17986448
- ↑ Kuma A, et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 277(21):18619-25 SGD PMID 11897782
- ↑ Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160
- ↑ Tanida I, et al. (1999) Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell 10(5):1367-79 SGD PMID 10233150
- ↑ Shintani T, et al. (1999) Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J 18(19):5234-41 SGD PMID 10508157
- ↑ Mizushima N, et al. (1998) A protein conjugation system essential for autophagy. Nature 395(6700):395-8 SGD PMID 9759731
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