YMR106C
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| Systematic name | YMR106C |
| Gene name | YKU80 |
| Aliases | HDF2 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:480189..478300 |
Description of YMR106C: Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair[1][2][3][4][5][6]
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References
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- ↑ Bertuch AA and Lundblad V (2003) The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini. Mol Cell Biol 23(22):8202-15 SGD PMID 14585978
- ↑ Boulton SJ and Jackson SP (1996) Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res 24(23):4639-48 SGD PMID 8972848
- ↑ Laroche T, et al. (1998) Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr Biol 8(11):653-6 SGD PMID 9635192
- ↑ Boulton SJ and Jackson SP (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 17(6):1819-28 SGD PMID 9501103
- ↑ Milne GT, et al. (1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol Cell Biol 16(8):4189-98 SGD PMID 8754818
- ↑ Martin SG, et al. (1999) Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97(5):621-33 SGD PMID 10367891
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